MITOGEL™ (mitomycin) urothelial gel, 0.4% , a novel prolonged-retention RTGel-based formulation of mitomycin, has the potential to become the first FDA-approved drug for the treatment of low-grade UTUC and to serve as a first-line chemoablation agent, potentially sparing patients from repeated tumor surgical procedures and reducing the need for kidney and upper urothelial tract removal.

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VESIGEL™ (mitomycin) urothelial gel, 0.18% , a novel prolonged-retention RTGel-based formulation of high dose mitomycin, has the potential to replace TURBT and become the new first-line standard of care for low-grade NMIBC. VESIGEL™, a chemoablation agent, is administered locally using standard catheters in a physician’s office, in comparison with TURBT conducted under general anesthesia in a hospital setting.

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VESIMUNE™ (imiquimod) , an immune-modulation product candidate, could represent a valid alternative to the current standard of care for the BCG adjuvant, post TURBT treatment of high-grade NMIBC. VESIMUNE™ ’s active ingredient is Imiquimod, an imidazoquinoline, synthetic immune modulator, which specifically targets TLR7, which is expressed in bladder cancer cells.

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About UroGen Pharma

UroGen Pharma  (“UroGen” or “the Company”) is a clinical-stage biopharmaceutical company focused on developing novel therapies designed to change the standard of care for urological pathologies with a focus on uro-oncology. The Company has an innovative and broad pipeline of product candidates that it believes can overcome the deficiencies of current treatment options.  The lead product candidates, MITOGEL™ (mitomycin) urothelial gel, 0.4% and VESIGEL™ (mitomycin) urothelial gel, 0.18% , are proprietary formulations of the chemotherapy drug Mitomycin, a generic drug which is currently used for urothelial cancer treatment in RTGel™,a novel proprietary polymeric biocompatible, reverse thermal gelation hydrogel. The Company’s clinical stage pipeline includes VESIMUNE™ (imiquimod), its proprietary immunotherapy product candidate for the treatment of carcinoma in situ.

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Clinical Trials


olympusThe OLYMPUS study

Optimized DeLivery of Mitomycin for Primary UTUC Study
Currently recruiting patients

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optimaThe OPTIMA study II

OPTimized Instillation of Mitomycin for BlAdder Cancer Treament
Commencement of patient recruitment planned for H1 2018